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Anti-HEPACAM [EPR11217] antibody (ab172635)抗肝細(xì)胞黏附分子抗體產(chǎn)品信息：

• Product nameAnti-HEPACAM [EPR11217] antibody
• Description

  Rabbit monoclonal [EPR11217] to HEPACAM

• Tested applicationsWB, ICC/IF
• Species reactivityReacts with: Human

  Does not react with

  Mouse, Rat
• Immunogen

  Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human HEPACAM aa 50-150 (Cysteine residue). The exact sequence is proprietary.
  Database link: Q14CZ8

• Positive control
  • Human fetal kidney, fetal liver, fetal brain and stomach lysates; HepG2 cells.
• General notes

  Produced under U.S. Patent No. 5,675,063.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
• Storage bufferpH: 7.2
  Preservative: 0.01% Sodium azide
  Constituents: 50% Glycerol, 49% PBS, 0.05% BSA
• PurityTissue culture supernatant
• ClonalityMonoclonal
• Clone numberEPR11217
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Cytoskeleton / ECM
  • Cell Adhesion
  • Cell Adhesion Molecules
  • Liver
  • Cancer
  • Invasion/microenvironment
  • ECM
  • Cell adhesion
  • Other

Applications

Our Abpromise guarantee covers the use of ab172635 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

• Application notesIs unsuitable for ,IHC-P or IP.

Target

• FunctionInvolved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.
• Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
  Contains 1 Ig-like V-type (immunoglobulin-like) domain.
• DomainThe cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility.
• Post-translational
  modificationsN-glycosylated.
• Cellular localizationCytoplasm. Membrane. In MCF7 breast carcinoma and hepatic Hep3B and HepG2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1.

• Database links

  • Entrez Gene: 220296 Human
  • Omim: 611642 Human
  • SwissProt: Q14CZ8 Human
  • Unigene: 159863 Human

Anti-HEPACAM [EPR11217] antibody images

• 

  Immunocytochemistry/ Immunofluorescence - Anti-HEPACAM [EPR11217] antibody (ab172635)

• Immunofluorescent analysis of HepG2 cells labeling HEPACAM with ab172635 at 1/250 dilution. DAPI nuclear staining (blue).

公司介紹：

    Abcam位于英國(guó)的劍橋科學(xué)園，成立于1998年，專門生產(chǎn)和分銷研究型抗體。主要?jiǎng)?chuàng)立人Jonathan Milner和實(shí)驗(yàn)室同事構(gòu)思成立一間了解科研人員需要的網(wǎng)上抗體公司，理念是Abcam銷售質(zhì)量高的抗體，并提供zui全面、誠(chéng)實(shí)、時(shí)新的說(shuō)明書，快速的送貨服務(wù)，及高效率的顧客和服務(wù)。我們的在線目錄(www.abcam.cn) 已有差不多100,000種抗體和試劑，并不斷添加，供應(yīng)予百多個(gè)國(guó)家。Abcam于2005年11月在倫敦證券交易所上市，在美國(guó)馬薩諸塞州、日本東京及香港均設(shè)有分公司。

    Abcam 一直致力加強(qiáng)產(chǎn)品線，為使研究員更容易找到蛋白質(zhì)研究試劑產(chǎn)品，在2011并購(gòu)了美國(guó)的MitoSciences公司，加強(qiáng)了免疫分析方面的產(chǎn)品供應(yīng)；同年也并購(gòu)了英國(guó)的Ascent Scientific 公司，開(kāi)展了生化試劑的供應(yīng)。在2012年，Abcam并購(gòu)了美國(guó)的Epitomics 公司，成為一家有的RabMAbs® 供應(yīng)商。

    Abcam 的 目標(biāo)是給世界上的抗體建立zui大的在線目錄，為各地科學(xué)家提供*產(chǎn)品，成為各國(guó)科學(xué)界的重要伙伴。我們?yōu)樗挟a(chǎn)品提供來(lái)使客戶獲得預(yù)期的結(jié) 果。為提供高質(zhì)量的抗體來(lái)指向盡可能多的靶蛋白，我們盡所能在盡可能多的應(yīng)用和物種中檢測(cè)每種抗體。我們相信誠(chéng)信才是上策，在我們的上會(huì)發(fā)布有關(guān)我們 每一種產(chǎn)品的盡可能多的信息。

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